• SAM-e (S-Adenosyl-L-methionine) 400mg
  • SAM-e (S-Adenosyl-L-methionine) 400mg
  • SAM-e (S-Adenosyl-L-methionine) 400mg
  • SAM-e (S-Adenosyl-L-methionine) 400mg
  • SAM-e (S-Adenosyl-L-methionine) 400mg
  • SAM-e (S-Adenosyl-L-methionine) 400mg

SAM-e (S-Adenosyl-L-methionine)

£ 21.45

£0.72 / tablet
(7) Reviews
400mg | 30 tablets

Improves ease of movement and joint mobility, and helps rebuild cartilage,

SAM-e (S-Adenosyl-L-methionine) - Supports, maintains and improves joint health - move with ease 


Benefits of Sam-e 

  • Helps maintain and improve joint health
  • Helps relieve pain and joint swelling
  • Improves ease of movement and joint mobility
  • Supports positive mood and energy levels
  • Helps maintain liver health

SAM-e is used to improve mobility, help rebuild cartilage, and may even help reduce symptoms of osteoarthritis (OA), fibromyalgia, bursitis, tendinitis, chronic low back pain, and depression.

SAM-e is a natural compound found in the body and is an amino acid derivative, which declines with age, and through illness. The highest concentrations are found in the liver, where it supports liver health and numerous complex enzymatic reactions. It is required for the synthesis of norepinephrine, dopamine, and serotonin in the brain. These brain chemicals are responsible for energy levels and mood.  

SAM-e works closely with the vitamins B12, B6 and folic acid, therefore it is important to have adequate B vitamins in the body when taking this supplement. It also helps glutathione usage, a potent antioxidant.

SAM-e is also a major component in the synthesis of nucleic acids, proteins, hormones, and phospholipids. In a 2002 U.S. Department of Health and Human Services study demonstrated it to be effective in helping maintain both mood stability and joint function. It also helps maintain acetylcholine levels, that are so important for correct cognitive function.

As a dietary supplement, adults take one enteric-coated tablet daily (a specific material which helps prevent or minimise dissolution in the stomach but allows dissolution in the small intestine), or as directed by a healthcare professional.

Store in a cool, dry place, away from direct light.

Do not exceed the recommended daily dose.

Keep out of reach of young children.

Children, pregnant women, and women who are breastfeeding should consult their doctor before use.

Nutritional supplements should not replace a varied and balanced diet and a healthy lifestyle.

Check with simultaneous intake of medicines with your physician or healthcare professional. No long-term use without professional advice.


SAM-e (from 800mg of s-adenosyl-l-methionine tosylate) 400mg.

Other Ingredients:

Cellulose, silica, magnesium stearate, ethyl cellulose, oleic acid, medium chain triglycerides, sodium alginate, modified cellulose, triacetin, calcium carbonate, and riboflavin (for colour).

Free from sugar, salt, dairy, wheat, gluten, corn, soy, preservatives, artificial colours or flavours.

Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule. Am J Clin Nutr. 2002 Nov;76(5):1151S-7S

Krzystanek M, Pałasz A, Krzystanek E, Krupka-Matuszczyk I, Wiaderkiewicz R, Skowronek R. S-adenosyl L-methionine in CNS diseases. Psychiatr Pol. 2011 Nov-Dec;45(6):923-31

Schrötter A, Pfeiffer K, El Magraoui F, Platta HW, Erdmann R, Meyer HE, Egensperger R, Marcus K, Müller T. The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease. Mol Cell Proteomics. 2012 Nov;11(11):1274-88

Halsted CH. B-Vitamin dependent methionine metabolism and alcoholic liver disease. Clin Chem Lab Med. 2013 Mar 1;51(3):457-65

Michael Brown J, Ball JG, Wright MS, Van Meter S, Valentovic MA. Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function. Toxicol Lett. 2012 Aug 3;212(3):320-8.

Sun 6th May 2018

Great product absolutely recommend

Wed 28th Mar 2018

I take this as part of a programme I'm on and can feel the benefit.

Mon 12th Feb 2018

As Above

Thu 8th Feb 2018

Easy to order and navigate websitePrompt, excellent customer service.

Fri 17th Aug 2018

Perfect for what I need. I've been using this brand and product for 11 months now and wouldn't change to another.

Fri 17th Aug 2018

Perfect for what I need. I've been using this brand and product for 11 months now and wouldn't change to another.

Sun 6th May 2018

Great product absolutely recommend

Customers Also Bought


Pay securely by Debit or Credit card or simply use your PayPal account.


We use a premier shipping partner to ensure quick and safe delivery.


We only source products that use premium quality ingredients.