Promotes heart health, healthy skin and helps maintain a healthy gastrointestinal tract
Folic Acid (with vitamin B12) - Promotes brain and heart health, and supports a healthy gastrointestinal tract
Benefits of Folic Acid
- Optimal levels promote cardiovascular health
- Supports neurotransmitter synthesis, helping to maintain cognitive health
- Helps maintain and support healthy homocysteine levels
- Supports energy levels and correct immune system functions
- Helps detoxify hormones such as oestrogens
- May help relieve hot flushes in menopause
- Enhances correct central nervous system function
Folic acid, a member of the vitamin B-complex family, and vitamin B12 work synergistically to promote brain and cardiovascular health.
Folic Acid with Vitamin B12
When Folic Acid and vitamin B12 are at optimal and balanced levels in the body, they help regulate homocysteine - both high and low homocysteine levels have been linked to cognitive decline and cardiovascular disease.
Folic Acid together with vitamin B12, is essential for central nervous system function, as they both help maintain the integrity of the myelin sheath of nerves.
Folic Acid works with vitamin B12 to help maintain the production of red blood cells (erythropoiesis) within the normal range.
Folic Acid plays many important roles in the body. It is especially important for energy production and correct immune system function. It helps detoxify hormones, such as oestrogens, and has been found to help relieve hot flushes during the menopause.
It is also needed to promote healthy DNA function, maintain normal homocysteine levels (together with vitamin B12), that are so important for heart health, promote healthier skin, help maintain a healthy GI tract, help maintain healthy endothelial function, and improve memory loss that is associated with the ageing process. Additionally, Folic Acid is required for the health of all tissues, particularly for the mucous membrane of the digestive tract, vagina, and cervix.
A healthy diet with sufficient folate may reduce the risk of a woman having a child with a brain or spinal cord defect. The average daily amount for women of childbearing age is 800mcg.
Vitamin B12 is needed to help support heart health by regenerating methionine, an amino acid, that helps maintain healthy homocysteine levels. Vitamin B12 also supports brain health and cognition as we age.
As a dietary supplement, adults take one tablet daily with meals, or as directed by a healthcare professional.
Store in a cool, dry place, away from direct light.
Do not exceed the recommended daily dose.
Keep out of reach of young children.
Children, pregnant women, and women who are breastfeeding should consult their doctor before use.
Nutritional supplements should not replace a varied and balanced diet and a healthy lifestyle.
Check with simultaneous intake of medicines with your physician or healthcare professional. No long-term use without professional advice.
Note: If taking digestive enzymes, it is best to wait two hours before taking folic acid as absorption of this vitamin may be affected.
Taking a high dosage of a single vitamin B may cause an imbalance between the other vitamin Bs in your system, therefore, you may wish to consider taking a B vitamin complex rather than take each B vitamin separately. A lack of just one single B vitamin can impact overall health as each B vitamin plays a specific role in the body.
Excessive dosages can cause insomnia, irritability, and gastrointestinal issues.
Folic acid may have an impact on certain medications - individuals on phenytoin (an anticonvulsant), for example, should not take high doses of folic acid.
Folic acid can also impact or interfere with seizure medication such as valproic acid, carbamazepine, and primidone, therefore it is always best to consult with your physician before ingesting this vitamin, especially if you are on any of these medications.
Folic Acid 800mcg, Vitamin B-12 (as cyanocobalamin) 25mcg.
Other ingredients: Magnesium stearate, cellulose, vegetable stearin, dicalcium phosphate and silica.
Free from salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, artificial colours or flavours.
Soheila Bani, Shirin Hasanpour, Leila Farzad Rik, Hadi Hasankhani and Seiedeh Hajar Sharami. The Effect of Folic Acid on Menopausal Hot Flashes: A Randomized Clinical Trial. J Caring Sci. 2013 Jun; 2(2): 131–140
Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials Homocysteine Lowering Trialists’ Collaboration.BMJ. 1998 Mar 21; 316(7135): 894–898
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002 Feb 14;346(7):476-83
Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA Butterworth C, et al. Folate deficiency and cervical dysplasia. JAMA 1992;267(4):528-533
Matherly LH. Molecular and cellular biology of the human reduced folate carrier. Prog Nucleic Acid Res Mol Biol. 2001;67:131-62
Stanger O. Physiology of folic acid in health and disease. Curr Drug Metab. 2002 Apr;3(2):211-23
van Oort FV, Melse-Boonstra A, Brouwer IA, Clarke R, West CE, Katan MB, Verhoef P. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study.Am J Clin Nutr. 2003 May;77(5):1318-23
Chang TY, Chou KJ, Tseng CF, Chung HM, Fang HC, Hung YM, Wu MJ, Tzeng HM, Lind CC, Lu KC.Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients. Curr Med Res Opin. 2007 Aug;23(8):1879-86
Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV.Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Environ Health Perspect. 2009 Feb;117(2):254-60
Williams JD, Jacobson MK.Photobiological implications of folate depletion and repletion in cultured human keratinocytes. J Photochem Photobiol B. 2010 Apr 2;99(1):49-61
Watkins D1, Rosenblatt DS.Update and new concepts in vitamin responsive disorders of folate transport and metabolism. J Inherit Metab Dis. 2012 Jul;35(4):665-70
Moens AL, Claeys MJ, Wuyts FL, Goovaerts I, Van Hertbruggen E, Wendelen LC, Van Hoof VO, Vrints CJ. Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol. 2007 Feb 15;99(4):476-81
Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P.Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet. 2007 Jan 20;369(9557):208-16
Am Fam Physician. 2010 Dec 15;82(12):1526-7
Maddox DM, Manlapat A, Roon P, Prasad P, Ganapathy V, Smith SBReduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart. BMC Dev Biol. 2003 Jul 29;3:6. Epub 2003 Jul 29.
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